Purpose There is a wide spectrum of tumor responsiveness of rectal adenocarcinomas to
preoperative chemoradiotherapy ranging from complete response to complete resistance�…

Chemoradiotherapy (CRT) represents a standard treatment for many human cancers,
frequently combined with radical surgical resection. However, a considerable percentage of�…

Purpose The prognosis of patients with pancreatic cancer remains poor, even after
potentially curative R0 resection. This discrepancy may be due to the histopathological�…

Chromosomal aneuploidies are a defining feature of carcinomas, ie, tumors of epithelial
origin. Such aneuploidies result in tumor specific genomic copy number alterations. The�…

We revisited the cytogenetic alterations of the cervical adenocarcinoma cell line HeLa
through the use of spectral karyotyping (SKY), comparative genomic hybridization (CGH)�…

Purpose: Numerous studies of circulating epithelial cells (CECs) have been described in
cancer patients, and genetic abnormalities have been well documented. However, with one�…

Measurement of the nuclear DNA content allows classification of human cancers as either
diploid or aneuploid. To gain further insight into mechanisms of aneuploidy, we compared�…

To screen pancreatic carcinomas for chromosomal aberrations we have applied molecular
cytogenetic techniques, including fluorescent in situ hybridization, comparative genomic�…

Purpose: To identify metabolic pathways that are perturbed in pancreatic ductal
adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of�…

Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF)
are particularly aggressive. To identify key signaling pathways that drive disease�…