THE vascular endothelial growth factor (VEGF) and its high-affinity binding receptors, the
tyrosine kinases Flt-1 and Flk-1, are thought to be important for the development of�…

THE receptor tyrosine kinase Flk-1 (ref. 1) is believed to play a pivotal role in endothelial
development. Expression of the Flk-1 receptor is restricted to endothelial cells and their�…

THE endothelial cell-specific vascular endothelial growth factor (VEGF) 1–5 and its cellular
receptors Flt-1 (refs 6, 7) and Flk-1 (refs 8, 9) have been implicated in the formation of the�…

Transgenic expression of just four defined transcription factors (c-Myc, Klf4, Oct4 and Sox2)
is sufficient to reprogram somatic cells to a pluripotent state,,,. The resulting induced�…

The receptor tyrosine kinases (RTKs) expressed on the surface of endothelial cells are likely
to play key roles in initiating the program of endothelial cell growth during development and�…

Placental development is profoundly influenced by oxygen (O2) tension. Human
cytotrophoblasts proliferate in vitro under low O2 conditions but differentiate at higher O2�…

Green fluorescent protein (GFP) and its variants currently represent the only non-invasive
markers available for labeling mammalian cells in culture or in a multicellular organism�…

Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To
evaluate the role of histamine, we generated HDC‐deficient mice using a gene targeting�…

The Cre/loxPsite-specific recombination system combined with embryonic stem cell-
mediated technologies has greatly expanded our capability to address normal and disease�…

Little is known about the genes that regulate telomere length diversity between mammalian
species. A candidate gene locus was previously mapped to a region on distal mouse Chr�…