Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor
family consistently associated with chromosomal translocation and functional fusion of the�…

Desmoplastic small round cell tumor (DSRCT) is a poorly understood neoplasm with
distinctive clinical, histologic and immunophenotypic features. It is associated with a novel�…

Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number�…

By means of in vivo selection, transcriptomic analysis, functional verification and clinical
validation, here we identify a set of genes that marks and mediates breast cancer metastasis�…

A search for general regulators of cancer metastasis has yielded a set of microRNAs for
which expression is specifically lost as human breast cancer cells develop metastatic�…

The molecular basis for breast cancer metastasis to the brain is largely unknown,. Brain
relapse typically occurs years after the removal of a breast tumour,,, suggesting that�…

Metastatic melanoma is a deadly cancer that fails to respond to conventional chemotherapy
and is poorly understood at the molecular level. p53 mutations often occur in aggressive and�…

Cells released from primary tumors seed metastases to specific organs by a nonrandom
process, implying the involvement of biologically selective mechanisms. Based on clinical�…

A new lung adenocarcinoma classification is being proposed by the International
Association for the Study of Lung Cancer, American Thoracic Society and European�…

We used bioluminescence imaging to reveal patterns of metastasis formation by human
breast cancer cells in immunodeficient mice. Individual cells from a population established�…