Abstract Significance: Hematopoietic stem cells (HSCs) can sustain the production of blood
throughout one's lifetime. However, for proper self-renewal of its own population and�…

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is
upregulated on activated T cells for the induction of immune tolerance,. Tumour cells�…

We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data�…

To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and�…

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge�…

Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need
for basic studies of immunoregulation in both adaptive cell lineages and innate cell�…

Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of
enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could�…

Stem-cell differentiation to desired lineages requires navigating alternating developmental
paths that often lead to unwanted cell types. Hence, comprehensive developmental�…

The mammalian brain contains neurogenic niches that comprise neural stem cells and other
cell types. Neurogenic niches become less functional with age, but how they change during�…

Interleukin-2 (IL-2) is a cytokine required for effector T cell expansion, survival, and function,
especially for engineered T cells in adoptive cell immunotherapy, but its pleiotropy leads to�…