Aneuploidy is one of the most obvious differences between normal and cancer cells.
However, there remains debate over how aneuploid cells arise and whether or not they are�…

Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and
aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct�…

Many errors in cell division lead to failure of cytokinesis and the generation of tetraploid
cells. Given that tetraploidy can have deleterious consequences, such as genetic instability�…

Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the
presence of extra centrosomes,,,. However, a direct mechanistic link between extra�…

The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of
debate, in large part because of the lack of insight into underlying mechanisms. Here we�…

Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead
to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because�…

Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to
overcome replicative mortality. ALT is mediated by recombination and is prevalent in a�…

Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest
that∼ 37% of human tumors have undergone a genome-doubling event during their�…

The human genome has three unique genes coding for kinesin-13 proteins called Kif2a,
Kif2b, and MCAK (Kif2c). Kif2a and MCAK have documented roles in mitosis, but the�…

Although the microtubule-depolymerizing KinI motor Kif2a is abundantly expressed in
neuronal cells, we now show it localizes to centrosomes and spindle poles during mitosis in�…