Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base�…

Helicases must unwind DNA at the right place and time to maintain genomic integrity or
gene expression. Biologically critical XPB and XPD helicases are key members of the�…

The ability to express or deplete proteins in living cells is crucial for the study of biological
processes. Viral vectors are often useful to deliver DNA constructs to cells that are difficult to�…

Mutations in XPD helicase, required for nucleotide excision repair (NER) as part of the
transcription/repair complex TFIIH, cause three distinct phenotypes: cancer-prone�…

Damaged bases in DNA are known to lead to errors in replication and transcription,
compromising the integrity of the genome. We have proposed a model where repair proteins�…

Recombinant expression of large, multiprotein complexes is essential and often rate limiting
for determining structural, biophysical, and biochemical properties of DNA repair, replication�…

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Using DNA-modified electrodes, we show DNA-mediated signaling by XPD, a helicase that
contains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription. The�…

The general transcription factor TFIIH contains three ATP-dependent catalytic activities.
TFIIH functions in nucleotide excision repair primarily as a DNA helicase and in Pol II�…

Human DNA polymerase η (HsPolη) plays an important role in translesion synthesis (TLS),
which allows for replication past DNA damage such as UV‐induced cis-syn cyclobutane�…