The Met receptor tyrosine kinase is the prototypic member of a small subfamily of growth
factor receptors that when activated induce mitogenic, motogenic, and morphogenic cellular�…

We report clinicopathologic features of a large series of renal translocation carcinomas from
a multicentric study. Diagnosis was performed by cytogenetic examination of fresh material�…

Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases,, and�…

The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large�…

Opisthorchis viverrini–related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major
public health concern in areas endemic for this parasite. We report here whole-exome�…

Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma
(PRCC2). The main effect of FH mutation is fumarate accumulation. The current paradigm�…

Complete loss or interstitial deletions of chromosome 5 are the most common karyotypic
abnormality in myelodysplastic syndromes (MDSs). Isolated del (5q)/5q–MDS patients have�…

The broad spectrum kinase inhibitor sunitinib is a first-line therapy for advanced clear cell
renal cell carcinoma (ccRCC), a deadly form of kidney cancer. Unfortunately, most patients�…

To better understand the molecular mechanisms that underlie the tumorigenesis and
progression of clear cell renal cell carcinoma (ccRCC), we studied the gene expression�…

Papillary renal cell carcinoma (RCC) represents 10% to 15% of adult renal neoplasms;
however, the molecular genetic events that are associated with the development and�…