The genomic plasticity of Candida albicans, a commensal and common opportunistic fungal
pathogen, continues to reveal unexpected surprises. Once thought to be asexual, we now�…

Candida species are the most common cause of opportunistic fungal infection worldwide.
Here we report the genome sequences of six Candida species and compare these and�…

Candida albicans has an elaborate, yet efficient, mating system that promotes conjugation
between diploid a and α strains. The product of mating is a tetraploid a/α cell that must�…

The ability of an organism to replicate and segregate its genome with high fidelity is vital to
its survival and for the production of future generations. Errors in either of these steps�…

Resistance to the limited number of available antifungal drugs is a serious problem in the
treatment of Candida albicans. We found that aneuploidy in general and a specific�…

Human fungal pathogens can exist in a variety of ploidy states, including euploid and
aneuploid forms. Ploidy change has a major impact on phenotypic properties, including the�…

TAC1, a Candida albicans transcription factor situated near the mating-type locus on
chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and�…

Genetic diversity is often generated during adaptation to stress, and in eukaryotes some of
this diversity is thought to arise via recombination and reassortment of alleles during�…

ABSTRACT TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation
of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida�…

Acquired azole resistance is a serious clinical problem that is often associated with the
appearance of aneuploidy and, in particular, with the formation of an isochromosome [i (5L)]�…