Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release�…

Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous.
CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the�…

Aneuploidy, an aberrant number of chromosomes in a cell, is a feature of several syndromes
associated with cognitive and developmental defects. In addition, aneuploidy is considered�…

Chromosomal instability (CIN) is an intricate phenomenon that is often found in human
cancer, characterized by persisting errors in chromosome segregation. This ongoing�…

Centrosome amplification is a common feature of human tumors, but whether this is a cause
or a consequence of cancer remains unclear. Here, we test the consequence of centrosome�…

Selective targeting of aneuploid cells is an attractive strategy for cancer treatment. However,
it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer�…

Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are
hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal�…

Background Chromosome instability leads to aneuploidy, a state in which cells have
abnormal numbers of chromosomes, and is found in two out of three cancers. In a�…

Chromosome segregation errors during cell divisions generate aneuploidies and
micronuclei, which can undergo extensive chromosomal rearrangements such as�…

Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in
cancer cells. Alterations in chromosome copy number induce a wide variety of cellular�…