Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of
reprogramming transcription factors. Expression levels of these factors strongly influence the�…

Mouse embryonic stem cells (mESC) exhibit cell cycle properties entirely distinct from those
of somatic cells. Here we investigated the cell cycle characteristics of human embryonic�…

Transcription factor (TF) networks are thought to regulate embryonic stem cell (ESC)
pluripotency. However, TF expression dynamics and regulatory mechanisms are poorly�…

The mechanisms underlying haematopoietic lineage decisions remain disputed. Lineage-
affiliated transcription factors, with the capacity for lineage reprogramming, positive auto�…

Investigating the signalling pathways that regulate heart development is essential if stem
cells are to become an effective source of cardiomyocytes that can be used for studying�…

Figure 1 Continuous single-cell quantification with tTt and qTfy.(a) Iterative image analysis
workflow of tTt: graphical overview of raw data for inspection and loading only of relevant�…

Human embryonic stem cells (hESCs) have great potential for use in research and
regenerative medicine, but very little is known about the factors that maintain these cells in�…

Transcription factors (TFs) and their networks are central effectors controlling pluripotency
(Young, 2011). Numerous involved TFs have been identified, but a subset of core�…

The application of human embryonic stem (hES) cells in regenerative medicine will require
rigorous quality control measures to ensure the safety of hES cell–derived grafts. During�…

Human embryonic stem (ES) cells are cultured cell lines derived from the inner cell mass of
the blastocyst that can be grown indefinitely in their undifferentiated state, yet also are�…