Introns are integral elements of eukaryotic genomes that perform various important functions
and actively partici-pate in gene evolution. We review six distinct roles of spliceosomal�…

It has been widely acknowledged that non-coding RNAs are master-regulators of genomic
functions. However, the significance of the presence of ncRNA within introns has not�…

To better understand the dual, tumour-suppressive and tumour-promoting function of
transforming growth factor-β (TGFβ), we analysed mammary epithelial NMuMG cells in�…

Patients with chronic renal failure develop a “uremic” cardiomyopathy characterized by
diastolic dysfunction, cardiac hypertrophy, and systemic oxidant stress. Patients with chronic�…

We have observed recently that experimental renal failure in the rat is accompanied by
increases in circulating concentrations of the cardiotonic steroid, marinobufagenin (MBG)�…

Among thousands of non-protein-coding RNAs which have been found in humans, a
significant group represents snoRNA molecules that guide other types of RNAs to specific�…

Objective Obese leptin deficient (ob/ob) mice are a model of adiposity that displays
increased levels of fat, glucose, and liver lipids. Our hypothesis is that HO‐1 overexpression�…

The cardiotonic steroid marinobufagenin (MBG) has been implicated in the pathogenesis of
experimental uremic cardiomyopathy, which is characterized by progressive cardiac fibrosis�…

The distribution of different intron groups with respect to phases has been analyzed. It has
been established that group II introns and nuclear introns have a minimum frequency of�…

Background Kidney injuries provoke considerable adjustment of renal physiology,
metabolism, and architecture to nephron loss. Despite remarkable regenerative capacity of�…