Chromosomal instability (CIN)—which is a high rate of loss or gain of whole or parts of
chromosomes—is a characteristic of most human cancers and a cause of tumour aneuploidy�…

Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples�…

The gut microbiome is suggested to play a role in the pathogenesis of autoimmune
disorders such as type 1 diabetes. Evidence of anti-islet cell autoimmunity in type 1 diabetes�…

Background The development of anti-islet cell autoimmunity precedes clinical type 1
diabetes and occurs very early in life. During this early period, dietary factors strongly impact�…

Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome
number and structure and generates intratumour heterogeneity,. CIN is observed in most�…

The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable�…

Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome
missegregation events in aneuploid cells promote chromosomal instability (CIN) that may�…

Chromosomal instability (CIN) is associated with poor prognosis in human cancer. However,
in certain animal tumor models elevated CIN negatively impacts upon organism fitness, and�…

Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics
with a poorly understood mechanism of action. We identified a set of genes repressed in�…

Aims/hypothesis Progression to type 1 diabetes in children and adolescents is not uniform.
Based on individual genetic background and environment, islet autoimmunity may develop�…