The rapid accumulation of complete genomic sequences offers the opportunity to carry out
an analysis of inter-and intra-individual genome variation within a species on a routine�…

Studying evolution in the laboratory provides a means of understanding the processes,
dynamics and outcomes of adaptive evolution in precisely controlled and readily replicated�…

Background We have developed and tested a method for printing protein microarrays and
using these microarrays in a comparative fluorescence assay to measure the abundance of�…

Genome rearrangements, especially amplifications and deletions, have regularly been
observed as responses to sustained application of the same strong selective pressure in�…

Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology
is not known. We have characterized one aspect of aneuploidy: the gain of extra�…

The experimental evolution of laboratory populations of microbes provides an opportunity to
observe the evolutionary dynamics of adaptation in real time. Until very recently, however�…

The decrease in sequencing cost and increased sophistication of assembly algorithms for
short-read platforms has resulted in a sharp increase in the number of species with genome�…

Aneuploidy causes a proliferative disadvantage in all normal cells analyzed to date, yet this
condition is associated with a disease characterized by unabated proliferative potential�…

High-quality, well-annotated genome sequences and standardized laboratory strains fuel
experimental and evolutionary research. We present improved genome sequences of three�…

Classical genetic approaches for interpreting variants, such as case-control or co-
segregation studies, require finding many individuals with each variant. Because the�…