Splicing of pre‐messenger RNA into mature messenger RNA is an essential step for the
expression of most genes in higher eukaryotes. Defects in this process typically affect�…

MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose�…

MicroRNAs (miRNAs) are released from cells in association with proteins or microvesicles.
We previously reported that malignant transformation changes the assortment of released�…

Chromosomal instability (CIN) underlies malignant properties of many solid cancers and
their ability to escape therapy, and it might itself cause cancer [1, 2]. CIN is sustained by�…

Canonical microRNA biogenesis requires the Microprocessor components, Drosha and
DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The�…

Amodel that explains both the origin and sporadic nature of cancer argues that cancer cells
are a chance result of events that cause genomic and epigenetic variability. The prevailing�…

Circulating microRNAs (miRNAs) have emerged as candidate biomarkers of various
diseases and conditions including malignancy and pregnancy. This approach requires�…

Hearing impairment is the most common sensory disorder, with congenital hearing
impairment present in approximately 1 in 1,000 newborns. Hereditary deafness is often�…

Pre-mRNA splicing is a crucial step in gene expression, and accurate recognition of splice
sites is an essential part of this process. Splice sites with weak matches to the consensus�…

Spinal muscular atrophy (SMA) is a neurological disorder characterized by motor neuron
degeneration and progressive muscle paralysis. The disease is caused by a reduction in�…