The ability to fuse cells is shared by many viruses, including common human pathogens and
several endogenous viruses. Here we will discuss how cell fusion can link viruses to cancer�…

Splicing of pre‐messenger RNA into mature messenger RNA is an essential step for the
expression of most genes in higher eukaryotes. Defects in this process typically affect�…

MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose�…

MicroRNAs (miRNAs) are released from cells in association with proteins or microvesicles.
We previously reported that malignant transformation changes the assortment of released�…

The recent findings that cell fusion may be involved in stem cell differentiation (Medvinsky
and Smith, 2003) raise a possibility that cell fusion has undiscovered functions, some of�…

Chromosomal instability (CIN) underlies malignant properties of many solid cancers and
their ability to escape therapy, and it might itself cause cancer [1, 2]. CIN is sustained by�…

Canonical microRNA biogenesis requires the Microprocessor components, Drosha and
DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The�…

Circulating microRNAs (miRNAs) have emerged as candidate biomarkers of various
diseases and conditions including malignancy and pregnancy. This approach requires�…

Amodel that explains both the origin and sporadic nature of cancer argues that cancer cells
are a chance result of events that cause genomic and epigenetic variability. The prevailing�…

Hearing impairment is the most common sensory disorder, with congenital hearing
impairment present in approximately 1 in 1,000 newborns. Hereditary deafness is often�…