The acquisition of genomic instability is a crucial step in the development of human cancer.
Genomic instability has multiple causes of which chromosomal instability (CIN) and�…

Accurate chromosome segregation relies on the precise regulation of mitotic progression.
Regulation involves control over the timing of mitosis and a spindle assembly checkpoint�…

The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid
separation until all chromosomes have achieved bipolar attachment to the mitotic spindle. Its�…

XRCC4 and XLF are two structurally related proteins that function in DNA double-strand
break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called�…

The ch-TOG/XMAP215 family of proteins bind directly to microtubules and appear to play an
essential role in stabilizing spindle microtubules. These proteins stabilize microtubules�…

In this paper, we show that substrate specificity is primarily conferred on human mitotic cyclin-
dependent kinases (CDKs) by their subcellular localization. The difference in localization of�…

Background Proper attachment of chromosomes to microtubules is crucial for the accurate
segregation of chromosomes. Human chromosomes attach initially to lateral walls of�…

The growth of artificial intelligence (AI) has led to an increase in the adoption of computer
vision and deep learning (DL) techniques for the evaluation of microscopy images and�…

The correct formation of stable but dynamic links between chromosomes and spindle
microtubules (MTs) is essential for accurate chromosome segregation. However, the�…

The microtubule polymer grows and shrinks predominantly from one of its ends called the
'plus-end'. Plus-end regulation during interphase is well understood. However, mitotic�…