The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the
antioxidative defense whose activity is altered in several chronic diseases, including�…

Aging skeletal muscles suffer a steady decline in mass and functional performance, and
compromised muscle integrity as fibrotic invasions replace contractile tissue, accompanied�…

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by a selective degeneration of motor neurons, atrophy, and paralysis of�…

One of the crucial systems severely affected in several neuromuscular diseases is the loss of
effective connection between muscle and nerve, leading to a pathological non�…

With advancing aging, a decline in physical abilities occurs, leading to reduced mobility and
loss of independence. Although many factors contribute to the physio-pathological effects of�…

We investigated the mechanism whereby expression of a transgene encoding a locally
acting isoform of insulin-like growth factor 1 (mIGF-1) enhances repair of skeletal muscle�…

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The effect of microgravity on skeletal muscles has so far been examined in rat and mice only
after short-term (5–20 day) spaceflights. The mice drawer system (MDS) program�…

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle atrophy and paralysis. To date, multiple panels of�…

The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia,
is the result of many factors including an imbalance between protein synthesis and�…