Proper chromosome segregation is required to maintain the appropriate number of
chromosomes from one cell generation to the next and to prevent aneuploidy, the condition�…

In mitotic cells, an error in chromosome segregation occurs when a chromosome is left near
the spindle equator after anaphase onset (lagging chromosome). In PtK1 cells, we found�…

The purpose of this review is to provide an historical overview of the molecular cytogenetic
approaches that have been pursed to identify the mechanism of origin of micronuclei as well�…

Defects in chromosome segregation play a critical role in producing genomic instability and
aneuploidy, which are associated with congenital diseases and carcinogenesis. We recently�…

To investigate the existence of an association between the frequency of chromosome
aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried�…

Posttranslational modifications of core histones contribute to driving changes in chromatin
conformation and compaction. Herein, we investigated the role of histone deacetylation on�…

We have characterized a nuclease hypersensitive chromatin fraction from murine
spermatozoa. Endogenous nuclease activity can be induced in mouse epididymal�…

Punica granatum L.(Punicaceae) whole fruit extracts, have been used in Cuban traditional
medicine as an effective drug for the treatment of respiratory diseases. This species showed�…

Macroautophagy/autophagy has been shown to exert a dual role in cancer ie, promoting cell
survival or cell death depending on the cellular context and the cancer stage. Therefore�…

We have developed a micronucleus test in the root tips of Vicia faba, as a first alarm system
for mutagen pollution of fresh water. The test can also give analytical results in the�…