Background—We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and
bone marrow transplantation to show that the infarct-sparing effect of A2AR activation at�…

Ischemia-reperfusion (I/R) injury occurs as a result of restoring blood flow to previously
hypoperfused vessels or after tissue transplantation and is characterized by inflammation�…

Abstract A 2A adenosine receptor (A 2A R)-expressing bone marrow (BM)-derived cells
contribute to the renal protective effect of A 2A agonists in renal ischemia-reperfusion injury�…

Activation of A2A adenosine receptors (A2ARs) protects kidneys from ischemia-reperfusion
injury (IRI). A2ARs are expressed on bone marrow–derived (BM-derived) cells and renal�…

Ischemia reperfusion injury results from tissue damage during ischemia and ongoing
inflammation and injury during reperfusion. Liver reperfusion injury is reduced by�…

High concentrations of adenosine in tumor microenvironments inhibit antitumor cytotoxic
lymphocyte responses. Although T cells express inhibitory adenosine A2A receptors (A2AR)�…

The role of monocytes/macrophages in the pathogenesis of ischemia-reperfusion injury (IRI)
is unknown. We sought to determine whether activation of macrophage adenosine 2A (A2A)�…

Chemokine CCL5/RANTES is highly expressed in cancer where it contributes to
inflammation and malignant progression. In this study, we show that CCL5 plays a critical�…

Neuropathic pain is a pathological symptom experienced worldwide by patients suffering
with nervous system dysfunction caused by various diseases. Treatment of neuropathic pain�…

The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs�…