The current COVID-19 pandemic presents a serious public health crisis, and a better
understanding of the scope and spread of the virus would be aided by more widespread�…

The idea that liquid–liquid phase separation (LLPS) may be a general mechanism by which
molecules in the complex cellular milieu may self-organize has generated much excitement�…

Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences�…

Cajal (coiled) bodies are conserved subnuclear organelles that are present in the
nucleoplasm of both animal and plant cells. Although Cajal bodies were first described�…

Folding of mammalian genomes into spatial domains is critical for gene regulation. The
insulator protein CTCF and cohesin control domain location by folding domains into loop�…

Constitutive heterochromatin is an important component of eukaryotic genomes that has
essential roles in nuclear architecture, DNA repair and genome stability, and silencing of�…

We imaged transcription in living cells using a locus-specific reporter system, which allowed
precise, single-cell kinetic measurements of promoter binding, initiation and elongation�…

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their
targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role�…

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin�…

INTRODUCTION DNA binding transcription factors (TFs) are quintessential regulators of
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding�…