The central nervous system is emerging as an important target for adverse health effects of
air pollution, where it may contribute to neurodevelopmental and neurodegenerative�…

Recent extensive evidence indicates that air pollution, in addition to causing respiratory and
cardiovascular diseases, may also negatively affect the brain and contribute to central�…

Objective To determine the effectiveness of physical activity interventions involving mobile
applications (apps) or trackers with automated and continuous self-monitoring and�…

The implementation of targeted therapies for acute myeloid leukaemia (AML) has been
challenging because of the complex mutational patterns within and across patients as well�…

Abstract Ca2+/calmodulin-dependent protein kinase II (CaMKII) is an enzyme with important
regulatory functions in the heart and brain, and its chronic activation can be pathological�…

Background: Nondisplaced scaphoid fractures treated with prolonged cast immobilization
may result in temporary joint stiffness and muscle weakness in addition to a delay in return�…

Little is known about the relative role of cAMP-dependent protein kinase (cAPK) and
guanine exchange factor directly activated by cAMP (Epac) as mediators of cAMP action. We�…

Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic
options. We previously combined ex vivo drug sensitivity with genomic, transcriptomic, and�…

The dose-dependent toxicity of the main psychoactive component of cannabis in brain
regions rich in cannabinoid CB1 receptors is well known in animal studies. However�…

Objective Epratuzumab, a monoclonal antibody that targets CD22, modulates B cell
signaling without substantial reductions in the number of B cells. The aim of this study was to�…