Pluripotent stem cells (PSCs) retain the ability to differentiate into a wide range of cell types
while undergoing self-renewal. They also exhibit an unusual mode of cell cycle regulation�…

Embryonic stem cells have the capacity for unlimited proliferation while retaining their
potential to differentiate into a wide variety of cell types. Murine, primate and human�…

A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is�…

Abstract During 2015–2016, record temperatures triggered a pan-tropical episode of coral
bleaching, the third global-scale event since mass bleaching was first documented in the�…

There exists a worldwide shortage of donor livers available for orthotropic liver
transplantation and hepatocyte transplantation therapies. In addition to their therapeutic�…

Background Selective serotonin reuptake inhibitors (SSRIs) have been suspected of
increasing the risk of bleeding. We examined the risk of upper gastrointestinal tract (GI)�…

Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-
dependent signaling. The downstream effectors of this pathway have not been previously�…

We used a yeast genetic screen to isolate cDNAs that encode a protein, SRF accessory
protein-l (SAP-l), that is recruited to the c-fos serum response element (ME) as part of a�…

Understanding the topological configurations of chromatin may reveal valuable insights into
how the genome and epigenome act in concert to control cell fate during development�…

THE c-myc protein (Myc) contains an amino-terminal transcriptional activation domain1 and
a carboxy-terminal basic helix–loop–helix–leucine zipper (bHLH-Z) domain2–5 that directs�…