The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the�…

Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to�…

The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types�…

Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the
organism. Embryonic stem cells are embryo-derived cell lines that retain pluripotency and�…

Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency
of iPSC derivation and the fact that most protocols modify the genome to effect cellular�…

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells
to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through�…

In tumor cells from virtually all patients with chronic myelogenous leukemia, the Philadelphia
chromosome, a fusion of chromosomes 9 and 22, directs the synthesis of the P210 bcr/abl�…

Tissue culture of immortal cell strains from diseased patients is an invaluable resource for
medical research but is largely limited to tumor cell lines or transformed derivatives of native�…

A major goal in human genetics is to understand the role of common genetic variants in
susceptibility to common diseases. This will require characterizing the nature of gene�…

Summary The Bcr-Abl tyrosine kinase oncogene causes chronic myelogenous leukemia
(CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL)�…