Chromosome instability and aneuploidy are hallmarks of cancer, but it is not clear how
changes in the chromosomal content of a cell contribute to the malignant phenotype�…

Using an expression cloning assay, we have isolated a novel cDNA, referred to as rsp-1,
which suppresses the v-Ras-transformed phenotype. When introduced into NIH 3T3�…

The link between Ras transformation and enhanced cell migration due to altered integrin
signaling is well established in tumorigenesis, however there remain gaps in our�…

Rsu-1 is a highly conserved leucine rich repeat (LRR) protein that is expressed ubiquitously
in mammalian cells. Rsu-1 was identified based on its ability to inhibit transformation by Ras�…

There are lines of evidence demonstrating that NEDD9 (Cas-L, HEF-1) plays a key role in
the development, progression, and metastasis of breast cancer cells. We previously reported�…

The mammary gland undergoes hormonally controlled cycles of pubertal maturation,
pregnancy, lactation, and involution, and these processes rely on complex signaling�…

Background Previous studies suggest that certain transition metal complexes, such as
cisplatin, are efficacious for treating various cancer types, including ovarian, lung, and�…

Background HC11 mouse mammary epithelial cells differentiate in response to lactogenic
hormone resulting in expression of milk proteins including β-casein. Previous studies have�…

CD44 adhesion molecules are expressed in many breast cancer cells and have been
demonstrated to play a key role in regulating malignant phenotypes such as growth�…

Studies were undertaken to determine the effect of the Ras suppressor Rsu-1 on Ras signal
transduction pathways in two different cell backgrounds. An expression vector containing the�…