The expression of genes is regulated at many levels. Perhaps the area in which least is
known is how nuclear organization influences gene expression. Studies of higher-order�…

The regulation of gene expression is mediated by interactions between chromatin and
protein complexes. The importance of where and when these interactions take place in the�…

Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of�…

A method of in situ hybridization for visualizing individual human chromosomes from pter to
qter, both in metaphase spreads and interphase nuclei, is reported. DNA inserts from a�…

Comparative genomic hybridization (CGH) to metaphase chromosomes has been widely
used for the genome‐wide screening of genomic imbalances in tumor cells. Substitution of�…

Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to
explore changes in epigenome structure and their functional implications during�…

We show that the nuclear architecture of rod photoreceptor cells differs fundamentally in
nocturnal and diurnal mammals. The rods of diurnal retinas possess the conventional�…

At the turn of this century, a few cytologists proposed the idea of a territorial organization of
chromosomes in the cell nucleus of animal and plant species (Rabl 1885; Strasburger 1905;�…

The nuclear lamins function in the regulation of replication, transcription, and epigenetic
modifications of chromatin. However, the mechanisms responsible for these lamin functions�…

Understanding nuclear architecture is indispensable for understanding the cell-type-
dependent orchestration of active and silent genes and other nuclear functions, such as�…