▪ Abstract SP-B is the only surfactant-associated protein absolutely required for postnatal
lung function and survival. Complete deficiency of SP-B in mice and humans results in�…

Retinoic acid receptor-related orphan receptors (RORs) regulate a variety of physiological
processes including hepatic gluconeogenesis, lipid metabolism, circadian rhythm, and�…

CC chemokine receptor-3 (CCR-3) is a major receptor involved in regulating eosinophil
trafficking; therefore, elucidation of ligand-induced CCR-3 events has important implications�…

Signal transduction pathways often use a transcriptional component to mediate adaptive
cellular responses. Coactivator proteins function prominently in these pathways as the�…

Aneuploid genomes, characterized by unbalanced chromosome stoichiometry (karyotype),
are associated with cancer malignancy and drug resistance of pathogenic fungi. The�…

The purpose of this study was to identify culture conditions for maintenance of isolated
mouse type II cells with intact surfactant protein (SP) and phospholipid production. Type II�…

Proteolytic processing of surfactant protein C (SP-C) proprotein in multivesicular bodies of
alveolar type II cells results in a 35-residue mature peptide, consisting of a transmembrane�…

Transcription factor ATF6α functions as a master regulator of endoplasmic reticulum (ER)
stress response genes. In response to ER stress, ATF6α translocates from its site of latency�…

Background The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic
threatened to oversaturate hospitals worldwide, necessitating rapid patient discharge to�…

Surfactant replacement preparations containing either surfactant protein (SP)-B or SP-C
significantly improve lung function in surfactant-deficient infants, suggesting that these�…