To be or not to be in the nucleolus
M Carmo-Fonseca, L Mendes-Soares, I Campos�- Nature cell biology, 2000 - nature.com
Compartmentalization has long been known to have a key role in regulation of cellular
processes. By keeping enzymes and regulatory complexes in compartments where the�…
processes. By keeping enzymes and regulatory complexes in compartments where the�…
Molecular mechanisms involved in cisplatin cytotoxicity
P Jordan, M Carmo-Fonseca*�- Cellular and Molecular Life Sciences�…, 2000 - Springer
cis-diamminedichloroplatinum (II) or cisplatin is a DNA-damaging agent that is widely used
in cancer chemotherapy. Cisplatin cross-links to DNA, forming intra-and interstrand adducts�…
in cancer chemotherapy. Cisplatin cross-links to DNA, forming intra-and interstrand adducts�…
Deep intronic mutations and human disease
R Vaz-Drago, N Cust�dio, M Carmo-Fonseca�- Human genetics, 2017 - Springer
Next-generation sequencing has revolutionized clinical diagnostic testing. Yet, for a
substantial proportion of patients, sequence information restricted to exons and exon–intron�…
substantial proportion of patients, sequence information restricted to exons and exon–intron�…
Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies
M Carmo-Fonseca, R Pepperkok, MT Carvalho…�- The Journal of cell�…, 1992 - rupress.org
We have recently shown that discrete foci are present in the nuclei of mammalian cells in
which each of the U1, U2, U4/U6, and U5 snRNPs involved in pre-mRNA splicing, and the�…
which each of the U1, U2, U4/U6, and U5 snRNPs involved in pre-mRNA splicing, and the�…
[HTML][HTML] Mammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing
Transcription is a highly dynamic process. Consequently, we have developed native
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which�…
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which�…
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36
Several lines of recent evidence support a role for chromatin in splicing regulation. Here, we
show that splicing can also contribute to histone modification, which implies bidirectional�…
show that splicing can also contribute to histone modification, which implies bidirectional�…
Dynamic association of RNA-editing enzymes with the nucleolus
JMP Desterro, LP Keegan, M Lafarga…�- Journal of cell�…, 2003 - journals.biologists.com
ADAR1 and ADAR2 are editing enzymes that deaminate adenosine to inosine in long
double stranded RNA duplexes and specific pre-mRNA transcripts. Here, we show that full�…
double stranded RNA duplexes and specific pre-mRNA transcripts. Here, we show that full�…
Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
K Weis, S Rambaud, C Lavau, J Jansen, T Carvalho…�- Cell, 1994 - cell.com
Acute promyelocytic leukemia (APL) is characterized by a specific t (l5; 17) translocation that
fuses the retinoic acid receptor a (RAFta) to a novel gene product, PML. The involvement of�…
fuses the retinoic acid receptor a (RAFta) to a novel gene product, PML. The involvement of�…
The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
Messenger RNAs are exported from the nucleus as large ribonucleoprotein complexes
(mRNPs). To date, proteins implicated in this process include TAP/Mex67p and RAE1/Gle2p�…
(mRNPs). To date, proteins implicated in this process include TAP/Mex67p and RAE1/Gle2p�…
The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body
T Carvalho, F Almeida, A Calapez, M Lafarga…�- The Journal of cell�…, 1999 - rupress.org
The spliceosomal snRNAs U1, U2, U4, and U5 are synthesized in the nucleus, exported to
the cytoplasm to assemble with Sm proteins, and reimported to the nucleus as�…
the cytoplasm to assemble with Sm proteins, and reimported to the nucleus as�…