Pluripotent stem cells constitute a platform to model disease and developmental processes
and can potentially be used in regenerative medicine. However, not all pluripotent cell lines�…

In recent years, genome-wide profiling approaches have begun to uncover the molecular
programs that drive developmental processes. In particular, technical advances that enable�…

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells
to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through�…

Microarray profiling of gene expression is a powerful tool for discovery, but the ability to
manage and compare the resulting data can be problematic. Biological, experimental, and�…

Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct
conversions between differentiated cell lineages represent powerful approaches to engineer�…

Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming
involves global epigenetic remodelling. Whereas several proteins are known to regulate�…

We compared bona fide human induced pluripotent stem cells (iPSCs) derived from
umbilical cord blood (CB) cells and neonatal keratinocytes (K). As a consequence of both�…

The Hippo-signaling pathway is an important regulator of cellular proliferation and organ
size. However, little is known about the role of this cascade in the control of cell fate�…

Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct
substates; however, the regulatory circuits specifying these states and enabling transitions�…

The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development,
tumorigenesis, and pluripotency, but their exact functions are poorly understood. Here, we�…