Recent studies have revealed extensive genetic diversity both between and within tumours.
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a�…

Cancer drug resistance is a major problem, with the majority of patients with metastatic
disease ultimately developing multidrug resistance and succumbing to their disease. Our�…

Chromosomal instability (CIN)—which is a high rate of loss or gain of whole or parts of
chromosomes—is a characteristic of most human cancers and a cause of tumour aneuploidy�…

Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome
number and structure and generates intratumour heterogeneity,. CIN is observed in most�…

The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable�…

Subclonal cancer populations change spatially and temporally during the disease course.
Studies are revealing branched evolutionary cancer growth with low-frequency driver events�…

Defining mechanisms that generate intratumour heterogeneity and branched evolution may
inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su�…

Background: Chromosomal instability (CIN) is thought to be associated with poor prognosis
in solid tumors; however, evidence from preclinical and mouse tumor models suggest that�…

Background Addition of taxanes to preoperative chemotherapy in breast cancer increases
the proportion of patients who have a pathological complete response (pCR). However, a�…

Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney
cancer. Here, we integrated an unbiased genome‐wide RNA interference screen for ccRCC�…