We describe a new basis for the construction of a genetic linkage map of the human
genome. The basic principle of the mapping scheme is to develop, by recombinant DNA�…

The past two decades have witnessed an explosion in the identification, largely by positional
cloning, of genes associated with mendelian diseases. The roughly 1,200 genes that have�…

Thousands of genes are being discovered for the first time by sequencing the genomes of
model organisms, an exhilarating reminder that much of the natural world remains to be�…

Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such�…

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity�…

Characteristic patterns of gene expression measured by DNA microarrays have been used
to classify tumors into clinically relevant subgroups. In this study, we have refined the�…

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's
lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and�…

Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces
apoptosis (programmed cell death) in target cells through the death receptor�…

Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such�…

The SUC2 gene of yeast (Saccharomyces) encodes two forms of invertase: a secreted,
glycosylated form, the synthesis of which is regulated by glucose repression, and an�…