Mitochondria in cells comprise a tubulovesicular network shaped continuously by
complementary fission and fusion events. The mammalian Drp1 protein plays a key role in�…

Voluntary movement is a fundamental way in which animals respond to, and interact with,
their environment. In mammals, the main CNS pathway controlling voluntary movement is�…

Human voluntary movement is controlled by the pyramidal motor system, a long CNS
pathway comprising corticospinal and lower motor neurons. Hereditary spastic paraplegias�…

Mitochondria in cells comprise a tubulovesicular reticulum shaped by dynamic fission and
fusion events. The multimeric dynamin-like GTPase Drp1 is a critical protein mediating�…

The endoplasmic reticulum (ER) consists of tubules that are shaped by the reticulons and
DP1/Yop1p, but how the tubules form an interconnected network is unknown. Here, we�…

Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death
are tightly regulated by the balance between fusion and fission processes. Excessive�…

INTRODUCTION The endoplasmic reticulum (ER) is a continuous, membrane-bound
organelle, spanning from the nuclear envelope to the outer cell periphery, that contacts and�…

Organelles move along differentially modified microtubules to establish and maintain their
proper distributions and functions,. However, how cells interpret these post-translational�…

In rat brain, the cellular localization of a phosphoinositide-linked metabotropic glutamate
receptor (mGluR1α) was demonstrated using antibodies that recognize the C-terminus of the�…

Autophagy allows cells to adapt to changes in their environment by coordinating the
degradation and recycling of cellular components and organelles to maintain homeostasis�…