[HTML][HTML] Guidelines for investigating causality of sequence variants in human disease
The discovery of rare genetic variants is accelerating, and clear guidelines for distinguishing
disease-causing sequence variants from the many potentially functional variants present in�…
disease-causing sequence variants from the many potentially functional variants present in�…
Microarrays and toxicology: the advent of toxicogenomics
EF Nuwaysir, M Bittner, J Trent…�- …�in cooperation with�…, 1999 - Wiley Online Library
The availability of genome‐scale DNA sequence information and reagents has radically
altered life‐science research. This revolution has led to the development of a new scientific�…
altered life‐science research. This revolution has led to the development of a new scientific�…
New IBD genetics: common pathways with other diseases
Complex disease genetics has been revolutionised in recent years by the advent of genome-
wide association (GWA) studies. The chronic inflammatory bowel diseases (IBDs), Crohn's�…
wide association (GWA) studies. The chronic inflammatory bowel diseases (IBDs), Crohn's�…
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Abstract Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the
action of multiple genetic and environmental risk factors. We report the findings of a genome�…
action of multiple genetic and environmental risk factors. We report the findings of a genome�…
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three�…
association studies. To advance gene discovery further, we combined data from three�…
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other�…
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other�…
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up�…
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up�…
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs�…
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs�…
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or�…
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or�…
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Y Miki, J Swensen, D Shattuck-Eidens, PA Futreal…�- Science, 1994 - science.org
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast
and ovarian cancer, has been identified by positional cloning methods. Probable�…
and ovarian cancer, has been identified by positional cloning methods. Probable�…