Gene therapy for neurological disorder is currently an experimental concept. The goals for
clinical utilization are the relief of symptoms, slowing of disease progression, and correction�…

Fibroblast growth factor-2 (FGF-2) promotes proliferation of neuroprogenitor cells in culture
and is up-regulated within brain after injury. Using mice genetically deficient in FGF-2 (FGF�…

Peripheral nerve transection results in the rapid death by apoptosis of neonatal but not adult
sensory and motor neurons. We show that this is due to induction and phosphorylation in all�…

Mitochondrial membrane potential (ΔΨm) is critical for maintaining the physiological function
of the respiratory chain to generate ATP. A significant loss of ΔΨm renders cells depleted of�…

Prolactin has a variety of important physiological effects on peripheral tissue and on the
brain. The behavioral effects of prolactin include the induction of maternal behavior and�…

Troyer syndrome is an autosomal recessive hereditary spastic paraplegia caused by
mutation in the spartin (SPG20) gene, which encodes a widely expressed protein of�…

Background Spartin protein is involved in degradation of epidermal growth factor receptor
and turnover of lipid droplets and a lack of expression of this protein is responsible for�…

Hereditary spastic paraplegias (HSPs, SPG1-46) are inherited neurological disorders
characterized by lower extremity spastic weakness. Loss-of-function SPG20 gene mutations�…

Nuclear protein peptidyl-prolyl isomerase Pin1-mediated prolyl isomerization is an essential
and novel regulatory mechanism for protein phosphorylation. Therefore, tight regulation of�…

Plants adjust to unfavorable conditions by altering physiological activities, such as gene
expression. Although previous studies have identified multiple stress-induced genes, the�…