INTRODUCTION Microglia, as the resident myeloid cells of the central nervous system, play
an important role in life-long brain maintenance and in pathology. Microglia are derived from�…

The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem
cells, and villi harboring differentiated cells. Spatial transcriptomics have demonstrated�…

Malignant cell growth is fueled by interactions between tumor cells and the stromal cells
composing the tumor microenvironment. The human liver is a major site of tumors and�…

The mammalian liver is composed of repeating hexagonal units termed lobules. Spatially
resolved single-cell transcriptomics has revealed that about half of hepatocyte genes are�…

The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is
spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones�…

Malaria infection involves an obligatory, yet clinically silent liver stage,. Hepatocytes operate
in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along�…

The liver is a polyploid organ, consisting of hepatocytes with one or two nuclei each
containing 2, 4, 8 or more haploid chromosome sets. The dynamic changes in the spatial�…

Single-cell RNA sequencing combined with spatial information on landmark genes enables
reconstruction of spatially-resolved tissue cell atlases. However, such approaches are�…

The intestinal epithelium is replaced every few days. Enterocytes are shed into the gut
lumen predominantly from the tips of villi, and have been believed to rapidly die upon their�…

Generation of beta cells via transdifferentiation of other cell types is a promising avenue for
the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and�…