If properly translated to clinical use, our knowledge about biomarkers may lead to a more
effective way of combating colorectal cancer (CRC). Biomarkers are biomolecular, genetic�…

During disease progression the cells that comprise solid malignancies undergo significant
changes in gene copy number and chromosome structure. Colorectal cancer provides an�…

Recent reports describe how genome-wide transcriptional analysis of cancer tissues can be
exploited to identify molecular signatures of immune infiltration in cancer. We hypothesize�…

Purpose: Aberrant promoter methylation and genomic instability occur frequently during
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown�…

High-density single nucleotide polymorphism (SNP) mapping arrays have identified
chromosomal features whose importance to cancer predisposition and progression is not yet�…

Group III metabotropic glutamate (mGlu) receptors are localized in presynaptic terminals
within basal ganglia (BG) circuitry that become hyperactive due to dopamine depletion in�…

Previous studies have shown that among populations with a high rate of consanguinity,
there is a significant increase in the prevalence of cancer. Single nucleotide polymorphism�…

Background The extraordinary invasiveness of human glioblastoma multiforme (GBM)
contributes to treatment failure and the grim prognosis of patients diagnosed with this tumor�…

Abstract Medulloblastoma (D-341 MED) and rhabdomyosarcoma (TE-671) cell lines, which
are resistant to either 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU) or the combination of�…

Background: MGMT (O6-methylguanine-DNA methyltransferase) is primarily responsible for
limiting the activity of some widely used chemotherapeutic agents, including temozolomide�…