In many sexually dimorphic species, a mechanism is required to ensure equivalent levels of
gene expression from the sex chromosomes. In mammals, such dosage compensation is�…

▪ Abstract The inactive X chromosome differs from the active X in a number of ways; some of
these, such as allocyclic replication and altered histone acetylation, are associated with all�…

In female mammals, one of the two X chromosomes in each cell is transcriptionally silenced
in order to achieve dosage compensation between the genders in a process called X�…

During mouse embryogenesis, reversion of imprinted X chromosome inactivation in the
pluripotent inner cell mass of the female blastocyst is initiated by the repression of Xist from�…

IN mammals, equal dosage of gene products encoded by the X chromosome in male and
female cells is achieved by X inactivation. Although X-chromosome inactivation represents�…

Coating of the X chromosome by Xist RNA is an essential trigger for X inactivation. However,
little is known about the early chromatin remodeling events that transform this signal into�…

The initial differential treatment of the two X chromosomes during X-chromosome
inactivation is controlled by the X-inactivation centre (Xic). This locus determines how many�…

The reprogramming of X-chromosome inactivation during the acquisition of pluripotency in
vivo and in vitro is accompanied by the repression of Xist, the trigger of X-inactivation, and�…

The Xist noncoding RNA is the key initiator of the process of X chromosome inactivation in
eutherian mammals, but its precise function and origin remain unknown. Although Xist is�…

The extra-embryonic endoderm lineage plays a major role in the nutritive support of the
embryo and is required for several inductive events, such as anterior patterning and blood�…