Fanconi anemia (FA) is a multigenic autosomal recessive cancer susceptibility syndrome.
The FA pathway regulates the monoubiquitination of FANCD2 and the assembly of damage�…

Checkpoints suppress improper cell cycle progression to ensure that cells maintain the
integrity of their genome. During mitosis, a metaphase checkpoint requires the integration of�…

The cellular response to DNA damage is composed of cell cycle checkpoint and DNA repair
mechanisms that serve to ensure proper replication of the genome prior to cell division. The�…

A “spindle assembly” checkpoint has been described that arrests cells in G1 following
inappropriate exit from mitosis in the presence of microtubule inhibitors. We have here�…

Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder
characterized by cellular sensitivity to mitomycin C and defective cell-cycle progression. Six�…

Fanconi anemia (FA) and ataxia telangiectasia (AT) are clinically distinct autosomal
recessive disorders characterized by spontaneous chromosome breakage and�…

BRCA1 and BRCA2 are prominently associated with inherited breast and ovarian cancer.
The encoded proteins function in DNA damage responses, but no functional link between�…

We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also
known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded�…

Protein phosphatase-1 (PP-1) is involved in the regulation of numerous metabolic processes
in mammalian cells. The major isoforms of PP-1, α, γ1, and δ, have nearly identical catalytic�…

Fanconi anemia (FA) is an autosomal recessive cancer susceptibility syndrome with at least
11 complementation groups (A, B, C, D1, D2, E, F, G, I, J, and L), and eight FA genes have�…