User profiles for "author:Altinok A"

Ahmet Altinok

University of Groningen
Verified email at rug.nl
Cited by 180

Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling

A Altinok, F L�vi, A Goldbeter�- european journal of pharmaceutical�…, 2009 - Elsevier
We use an automaton model for the cell cycle to assess the toxicity of various circadian
patterns of anticancer drug delivery so as to enhance the efficiency of cancer chronotherapy�…

Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy

JW Young, JCW Locke, A Altinok, N Rosenfeld…�- Nature protocols, 2012 - nature.com
Quantitative single-cell time-lapse microscopy is a powerful method for analyzing gene
circuit dynamics and heterogeneous cell behavior. We describe the application of this�…

[HTML][HTML] Dynamic heterogeneity and DNA methylation in embryonic stem cells

ZS Singer, J Yong, J Tischler, JA Hackett, A Altinok…�- Molecular cell, 2014 - cell.com
Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each
exhibiting stochastic noise in its gene expression. A major challenge is to disentangle these�…

A cell cycle automaton model for probing circadian patterns of anticancer drug delivery

A Altinok, F L�vi, A Goldbeter�- Advanced drug delivery reviews, 2007 - Elsevier
To optimize the temporal patterning of drug delivery used in cancer chronotherapy, we resort
to an automaton model describing the transitions through the successive phases of the cell�…

Implications of circadian clocks for the rhythmic delivery of cancer therapeutics

F L�vi, A Altinok, J Clairambault…�- …�Transactions of the�…, 2008 - royalsocietypublishing.org
The circadian timing system (CTS) controls drug metabolism and cellular proliferation over
the 24 hour day through molecular clocks in each cell. These cellular clocks are coordinated�…

[PDF][PDF] Temporal integration for continuous multimodal biometrics

A Altinok, M Turk�- Proceedings of the Workshop on Multimodal User�…, 2003 - Citeseer
Typically, biometric systems authenticate the user at a particular moment in time, granting or
denying access to resources for the complete session. This model of authentication does not�…

Factors influencing central corneal thickness in a Turkish population

A Altinok, E Sen, A Yazici, FN Aksakal…�- Current Eye�…, 2007 - Taylor & Francis
Purpose: The aim of this study is to find out the central corneal thickness (CCT) values for a
Turkish patient group and to investigate the possible influences of age, sex, IOP, refractive�…

[HTML][HTML] Calcium signals are necessary to establish auxin transporter polarity in a plant stem cell niche

T Li, A Yan, N Bhatia, A Altinok, E Afik…�- Nature�…, 2019 - nature.com
In plants mechanical signals pattern morphogenesis through the polar transport of the
hormone auxin and through regulation of interphase microtubule (MT) orientation. To date�…

[HTML][HTML] Training machine learning models on climate model output yields skillful interpretable seasonal precipitation forecasts

PB Gibson, WE Chapman, A Altinok…�- …�Earth & Environment, 2021 - nature.com
A barrier to utilizing machine learning in seasonal forecasting applications is the limited
sample size of observational data for model training. To circumvent this issue, here we�…

An automaton model for the cell cycle

A Altinok, D Gonze, F L�vi, A Goldbeter�- Interface focus, 2011 - royalsocietypublishing.org
We consider an automaton model that progresses spontaneously through the four
successive phases of the cell cycle: G1, S (DNA replication), G2 and M (mitosis). Each�…