Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring�…

Phosphate is one of the most abundant minerals in the body, and its serum levels are
regulated by a complex set of processes occurring in the intestine, skeleton, and kidneys�…

A recurring theme in biological circuits is the existence of components that are
antagonistically bifunctional, in the sense that they simultaneously have two opposing�…

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to�…

Oligonucleotide arrays can provide a broad picture of the state of the cell, by monitoring the
expression level of thousands of genes at the same time. It is of interest to develop�…

Complex networks are studied across many fields of science. To uncover their structural
design principles, we defined “network motifs,” patterns of interconnections occurring in�…

Little is known about the design principles 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 of transcriptional
regulation networks that control gene expression in cells. Recent advances in data�…

Engineered systems are often built of recurring circuit modules that carry out key functions.
Transcription networks that regulate the responses of living cells were recently found to obey�…

The tumor suppressor p53, one of the most intensely investigated proteins,,,,, is usually
studied by experiments that are averaged over cell populations, potentially masking the�…

E. coli is widely used for systems biology research; there exists a need, however, for tools
that can be used to accurately and comprehensively measure expression dynamics in�…