Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of�…

Background The in vitro generation of neurons from embryonic stem (ES) cells is a
promising approach to produce cells suitable for neural tissue repair and cell-based�…

Heterogeneous expression of the transcription factor NANOG has been linked to the
existence of various functional states in pluripotent stem cells. This heterogeneity seems to�…

Embryonic stem (ES) cells have been shown to differentiate in vitro into a wide variety of cell
types having significant potential for tissue regeneration. Therefore, the operational�…

The number of individuals suffering from neuropsychiatric disorders (NPDs) has increased
worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research�…

Background The pluripotent state in embryonic stem (ES) cells is controlled by a core
network of transcription factors that includes Nanog, Oct4 and Sox2. Nanog is required to�…

Elevated levels of serum unconjugated bilirubin (UCB) in the first weeks of life may lead to
long‐term neurologic impairment. We previously reported that an early exposure of�…

The potential of regenerative medicine is beginning to be realized. With more than 30
human pluripotent stem cell (hPSC) clinical trials in progress and a handful of approved�…

A detailed stochastic model of single-gene autoregulation is established and its solutions
are explored when mRNA dynamics is fast compared with protein dynamics and in the�…

Maintenance of embryonic stem cell (ESC) self-renewal and pluripotency are controlled by
extrinsic factors, molecular signaling pathways and transcriptional regulators. While many of�…