[HTML][HTML] Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions

PF Wu, QQ Han, FF Chen, TT Shen, YH Li, Y Cao…�- Neurobiology of�…, 2021 - Elsevier
Emerging evidence has shown that stress responsivity and psychiatric diseases are
associated with alterations in N 6-methyladenosine (m 6 A) mRNA epigenetic modifications�…

[HTML][HTML] The role of m6A/m-RNA methylation in stress response regulation

M Engel, C Eggert, PM Kaplick, M Eder, S R�h, L Tietze…�- Neuron, 2018 - cell.com
Summary N 6-methyladenosine (m 6 A) and N 6, 2′-O-dimethyladenosine (m 6 Am) are
abundant mRNA modifications that regulate transcript processing and translation. The role�…

Early-life m6A RNA demethylation by fat mass and obesity-associated protein (FTO) influences resilience or vulnerability to heat stress later in life

T Kisliouk, T Rosenberg, O Ben-Nun, M Ruzal, N Meiri�- eneuro, 2020 - eneuro.org
Early life heat stress leads to either resilience or vulnerability to a similar stress later in life.
We have previously shown that this tuning of the stress response depends on neural�…

[HTML][HTML] Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

S Liu, J Xiu, C Zhu, K Meng, C Li, R Han, T Du…�- Nature�…, 2021 - nature.com
Post-transcriptional modifications of RNA, such as RNA methylation, can epigenetically
regulate behavior, for instance learning and memory. However, it is unclear whether RNA�…

FTO: an emerging molecular player in neuropsychiatric diseases

PK Annapoorna, H Iyer, T Parnaik, H Narasimhan…�- Neuroscience, 2019 - Elsevier
A myriad of chemical modifications of DNA and histones involved in the epigenetic
regulation of neural gene expression have been documented and studied in detail since�…

RNA methylations in depression, from pathological mechanism to therapeutic potential

C Li, P Xu, Y Huang, Y Wang, Y Wu, H Li…�- Biochemical�…, 2023 - Elsevier
Depression is caused by a variety of factors such as genetic factors, biological factors, and
psychosocial factors, and the pathogenesis is complex. RNA methylations and related�…

[HTML][HTML] Potential roles of m6A and FTO in synaptic connectivity and major depressive disorder

H Mitsuhashi, C Nagy�- International journal of molecular sciences, 2023 - mdpi.com
RNA modifications known as epitranscriptomics have emerged as a novel layer of
transcriptomic regulation. Like the well-studied epigenetic modifications characterized in�…

Role of Fto on CaMKII/CREB signaling pathway of hippocampus in depressive-like behaviors induced by chronic restraint stress mice

J Shen, L Yang, W Wei�- Behavioural brain research, 2021 - Elsevier
Background Major depressive disorders (MDD) is one of the most common mental illness in
the world. Recently, brain m 6 A/m (fat mass-and obesity-associated gene Fto) was found�…

[HTML][HTML] Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons

KD Meyer, Y Saletore, P Zumbo, O Elemento…�- Cell, 2012 - cell.com
Methylation of the N 6 position of adenosine (m 6 A) is a posttranscriptional modification of
RNA with poorly understood prevalence and physiological relevance. The recent discovery�…

Mechanism of METTL3‐mediated m6A modification in depression‐induced cognitive deficits

J Niu, B Wang, T Wang, T Zhou�- American Journal of Medical�…, 2022 - Wiley Online Library
Depressive disorder (DD) is associated with N6‐methyladenosine (m6A) hypermethylation.
This study sought to explore the molecular mechanism of Methyltransferase‐like 3 (METTL3)�…