The biosynthetic pathway of vitamin C in higher plants

GL Wheeler, MA Jones, N Smirnoff�- Nature, 1998 - nature.com
Vitamin C (l-ascorbic acid) has important antioxidant and metabolic functions in both plants
and animals, but humans, and a few other animal species, have lost the capacity to�…

Vitamin C degradation in plant cells via enzymatic hydrolysis of 4-O-oxalyl-l-threonate

MA Green, SC Fry�- Nature, 2005 - nature.com
Increasing the l-ascorbate (vitamin C) content of crops could in principle involve promoting
its biosynthesis or inhibiting its degradation. Recent progress has revealed biosynthetic�…

Missing step in man, monkey and guinea pig required for the biosynthesis of L-ascorbic acid

JJ Burns�- Nature, 1957 - nature.com
MAN, other primates and guinea pig are the only mammals that are known to be unable to
synthesize l-ascorbic acid; thus they require vitamin C in their diet to prevent scurvy. The rat�…

BIOSYNTHESIS OF ASCORBIC ACID IN PLANTS: A Renaissance

N Smirnoff, PL Conklin…�- Annual review of plant�…, 2001 - annualreviews.org
▪ Abstract The structure of the familiar antioxidant l-ascorbic acid (vitamin C) was described
in 1933 yet remarkably, its biosynthesis in plants remained elusive until only recently. It�…

L-ascorbic acid biosynthesis

N Smirnoff�- Vitamins & Hormones, 2001 - Elsevier
Biosynthesis of l-ascorbate (vitamin C) occurs by different pathways in plants and mammals.
Yeast contain d-erythroascorbate, a C 5 analog of ascorbate. UDP-d-glucuronic acid is the�…

Reduction of dehydroascorbic acid by animal tissues

RE Hughes�- Nature, 1964 - nature.com
IT has long been known that an enzyme catalysing the reduction of dehydro-l-ascorbic acid
(DHA) by glutathione to ascorbic acid occurs in plant tissues1–3. It can also be shown that�…

Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant

V Valpuesta, MA Botella�- Trends in plant science, 2004 - cell.com
The biosynthetic pathway of L-ascorbic acid (vitamin C) in plants has been established for
several years. However, recent reports describe alternative pathways, revealing a more�…

[HTML][HTML] Vitamin C exhibits pro-oxidant properties

ID Podmore, HR Griffiths, KE Herbert, N Mistry, P Mistry…�- Nature, 1998 - nature.com
Vitamin C exhibits pro-oxidant properties | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best�…

Ascorbic acid in plants: biosynthesis and function

N Smirnoff, GL Wheeler�- Critical reviews in plant sciences, 2000 - Taylor & Francis
Ascorbic acid (vitamin C) is an abundant component of plants. It reaches a concentration of
over 20 m M in chloroplasts and occurs in all cell compartments, including the cell wall. It�…

L-ascorbic acid metabolism in the ascorbate-deficient Arabidopsis mutant vtc1

PL Conklin, JE Pallanca, RL Last, N Smirnoff�- Plant Physiology, 1997 - academic.oup.com
The biosynthesis of L-ascorbic acid (vitamin C) is not well understood in plants. The ozone-
sensitive Arabidopsis thaliana mutant vitamin c-1 (vtc1; formerly known as soz1) is deficient�…