It is not fully understood why COVID-19 is typically milder in children,–. Here, to examine the
differences between children and adults in their response to SARS-CoV-2 infection, we�…

Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals,–, many others experience milder�…

Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the�…

Interferon deficiency can lead to severe COVID Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best�…

After extremely low case rates in New York City early this summer, the number of children
testing positive for SARS-CoV-2 has begun to rise. Credit: Spencer Platt/GettyEarly last year�…

There has been substantial research on adult COVID-19 and how to treat it. But how do
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections afflict children�…

To the Editor—As the COVID Human Genetic Effort consortium (https://www. covidhge.
com/), we have studied genetic and immunological determinants of life-threatening COVID�…

Most studies of adaptive immunity to SARS-CoV-2 infection focus on peripheral blood, which
may not fully reflect immune responses at the site of infection. Using samples from 110�…

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to
spread relentlessly, associated with a high frequency of respiratory failure and mortality�…

Recent studies have provided insights into the pathology of and immune response to COVID-
19,,,,,,–. However, a thorough investigation of the interplay between infected cells and the�…