Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate�…

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a�…

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion�…

Excitatory synaptic transmission in the brain is mediated by ligand-gated ion channels
(iGluRs) activated by glutamate. Distinct from other neurotransmitter receptors, the�…

As in the case of many ligand-gated ion channels, the biochemical and electrophysiological
properties of the ionotropic glutamate receptors have been studied extensively�…

Glutamate RECEPTORS are the primary excit-atory neurotransmitter receptors in the
mammalian CNS, and are of importance to a wide variety of neuronal functions. They are�…

Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the
central nervous system and function by opening their ion channel in response to binding of�…

In native brain membranes the principal excitatory neurotransmitter L-glutamate activates
cation-conducting channels with distinct biophysical and pharmacological properties�…

Glutamate receptors are critically important for normal brain function. The preceding decade
has seen remarkable advances in our understanding of the physiological function and�…

▪ Abstract A vast number of proteins are involved in synaptic function. Many have been
cloned and their functional role defined with varying degrees of success, but their number�…