The potential contributions of the brain histaminergic system in neurodegenerative diseases,
and the possiblity of histamine-targeting treatments is attracting considerable interests. The�…

Histamine and its receptors were first described as part of immune and gastrointestinal
systems, but their presence in the central nervous system and importance in behavior are�…

The G i/o protein-coupled histamine H 3 receptor is distributed throughout the central
nervous system including areas like cerebral cortex, hippocampus and striatum with the�…

The H3 histamine receptor is expressed in many brain regions, including those involved in
sleep/wake regulation and cognitive functions. Inhibition of the H3 receptor leads to�…

Histamine has long been known to trigger allergic reactions and gastric acid secretion.
However, it was later discovered that, in the brain, histamine regulates basic homeostatic�…

Histamine H 3 receptor pharmacology, functions and biochemistry are far from being fully
understood; however, progress is being made. Activation of this G i/G o-protein-coupled�…

Histamine in the brain is produced by a group of tuberomamillary neurons in the posterior
hypothalamus and a limited number of mast cells in different parts of the brain. Four G�…

Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus,
from where they project to many brain areas. The histaminergic system is involved in basic�…

During the last decade, the identification of a number of novel drug targets led to the
development of promising new compounds which are currently under evaluation for their�…

The successful cloning and functional expression of the histamine H3 receptor in the late
1990s has greatly facilitated our efforts to identify small molecule, non-imidazole based�…