The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a
central focus for engaging the immune system in the fight against cancer. Basic science�…

The recent clinical successes of immune checkpoint blockade and chimeric antigen receptor
T cell therapies represent a turning point in cancer immunotherapy. These successes also�…

Simple Summary Immunotherapy helps a person's immune system to target tumor cells.
Recent advances in cancer immunotherapy, including immune checkpoint inhibition�…

Cancer immunotherapy has dramatically changed the approach to cancer treatment. The
aim of targeting the immune system to recognize and destroy cancer cells has afforded�…

Immunotherapy strategies against cancer are emerging as powerful weapons for treatment
of this disease. The success of checkpoint inhibitors against metastatic melanoma and�…

Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous�…

Recent advances in cancer immunotherapy have directly built on 50 years of fundamental
and technological advances that made checkpoint blockade and T cell engineering�…

Cancer is a condition that has plagued humanity for thousands of years, with the first
depictions dating back to ancient Egyptian times. However, not until recent decades have�…

Cancer is a worldwide medical problem with significant repercussions on individual patients
and societies as a whole. In order to alter the outcomes of this deadly disease the treatment�…

Immunotherapy is often perceived as a relatively recent advance. In reality, however, one
should be looking for the beginnings of cancer immunotherapy under different names as far�…