Neurobiologic Advances from the Brain Disease Model of Addiction | New England Journal of
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An updated and expanded edition on the roles that brain function and genetics play in
addiction. Over the past 10 years, neurobiologic and genetic research has provided an�…

The United States is stuck in its drug abuse metaphors and in po-larized arguments about
them. Everyone has an opinion. One side insists that'we must control supply, the other that�…

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug‐
seeking and drug‐taking behaviours. Given the significant detrimental effects of this disease�…

At the end of the decade of the brain, the study of neural mechanisms has come to dominate
the study of addiction. Whereas attention was once on somatic withdrawal symptoms and�…

Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence�…

Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems
in the brain that are responsible for drug addiction. Common neurobiological elements are�…

George F. Koob,* Pietro Paolo Sanna, and Floyd E. Bloom diction (Koob and Le Moal, 1997;
Koob et al., 1998). The underlying molecular and cellular changes that Department of�…

Addiction can be defined in part as a compulsion to use alcohol or other drugs and the
occurrence of withdrawal symptoms when long-term consumption ceases. In addition to�…

Modern neuroscience has greatly increased our understanding of the phenomenology of
addiction. Using animal models as well as human brain imaging studies and clinical�…