Background Vitamin C is an essential water-soluble nutrient which cannot be synthesised or
stored by humans. It is a potent antioxidant with anti-inflammatory and immune-supportive�…

Introduction Recent reports have highlighted the prevalence of vitamin D deficiency and
suggested an association with excess mortality in critically ill patients. Serum vitamin D�…

Background Supplementation of vitamin C in septic patients remains controversial despite
eight large clinical trials published only in 2020. We aimed to evaluate the evidence on�…

Introduction We conducted the present study to evaluate the changes in serum total
antioxidant capacity (TAC) in patients with severe sepsis and to investigate the association�…

Background Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis
were limited by short-term vitamin C administration, heterogeneous populations, and the�…

Introduction Hypocalcemia is common in critically ill patients. However, its clinical course
during the early days of admission and the role of calcium supplementation remain�…

Introduction Liver dysfunction associated with artificial nutrition in critically ill patients is a
complication that seems to be frequent, but it has not been assessed previously in a large�…

Introduction Septic encephalopathy secondary to a breakdown of the blood-brain barrier
(BBB) is a known complication of sepsis. However, its pathophysiology remains unclear. The�…

Introduction Both C-reactive protein (CRP) and procalcitonin (PCT) are accepted sepsis
markers. However, there is still some debate concerning the correlation between their serum�…

Introduction Vitamin D deficiency is encountered frequently in critically ill patients and might
be harmful. Current nutrition guidelines recommend very low vitamin D doses. The objective�…