The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to
sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized�…

PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of
a PTEN pseudogene expressed noncoding RNA, PTENpg1. Here, we characterize a�…

The development of life-threatening cancer metastases at distant organs requires
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different�…

Abstract Small (< 200 nucleotide) RNA (sRNA) profiling of human cells using various
technologies demonstrates unexpected complexity of sRNAs with hundreds of thousands of�…

We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs
to regulate mRNA transcripts containing common microRNA recognition elements (MREs)�…

Because they are generally noncoding and thus considered nonfunctional and unimportant,
pseudogenes have long been neglected. Recent advances have established that the DNA�…

Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this�…

The tumour stroma is believed to contribute to some of the most malignant characteristics of
epithelial tumours. However, signalling between stromal and tumour cells is complex and�…

Functional genomics has provided evidence that the human genome transcribes a large
number of non-coding genes in addition to protein-coding genes, including microRNAs and�…

The transcriptomes of eukaryotic cells are incredibly complex. Individual non-coding RNAs
dwarf the number of protein-coding genes, and include classes that are well understood as�…