The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and�…

Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus�…

Computational models of hippocampal function propose that the hippocampus is capable of
rapidly storing distinct representations through a process known as pattern separation. This�…

Pattern separation is a process that minimizes overlap between patterns of neuronal activity
representing similar experiences. Theoretical work suggests that the dentate gyrus (DG)�…

We sought to explore the roles of the hippocampal subregions and adjacent medial
temporal lobe regions in pattern separation and any differential contributions based on�…

Episodic memory depends on the computational process of pattern separation in order to
establish distinct memory representations of similar episodes. Studies of pattern separation�…

Pattern separation, or the process by which highly similar stimuli or experiences in memory
are represented by non-overlapping neural ensembles, has typically been ascribed to�…

Pattern separation is a basic principle of neuronal coding that precludes memory
interference in the hippocampus. Its existence is supported by numerous theoretical�…

The hippocampus is proposed to be critical in distinguishing between similar experiences by
performing pattern separation computations that create orthogonalized representations for�…

Pattern separation, the process of transforming similar representations or memories into
highly dissimilar, nonoverlapping representations, is a key component of many functions�…